|
-
Positions and
Honors
1989 Visiting Scientist, Imperial Cancer Research Fund, England, United
Kingdom
1989 - 1990 Postdoctoral Research Associate, Section of Biochemistry,
Cornell University
1990 - 1992 Postdoctoral NSF Fellow, Howard Hughes Medical Institute,
UMass Medical Center, Worcester, MA
1992 - 1996 Assistant Professor, Dept of Chemistry, University of
Puerto Rico, San Juan, PR
1996 - 2001 Associate Professor, Dept of Chemistry, Universito of
Puerto Rico, San Juan, PR
2001 - present Professor, Dept. of Chemistry, University of Puerto
Rico, San Juan, PR
2001 - present Adjunct Professor, Dept. of Biochemistry, University
of Puerto Rico, Medical Sciences Campus, San Juan, PR
Glaxo Wellcome Research
Award 2000 - Basic Sciences First Prize, Experienced Researcher
Alfred P. Sloan Research Fellow in Neuroscience 1994-1996
Oak Ridge Associated Universities (ORAU) Junior Faculty Enhancement Award
1993
National Science Foundation Minority Postdoctoral Fellowship 1990-1992
Biotechnology Program Predoctoral Fellowship, Cornell University 1986-1989
MARC-NIH Predoctoral Fellowship 1984-1986
Natural Sciences Faculty Prize, UPR 1984
B.S. Magna Cum Laude, UPR 1984
MARC-NIH Honors Undergraduate Fellowship, UPR 1982-1984
MBRS-NIH (SUBE) Fellowship, UPR 1981-1982
Four times Dean's List and Honors Tuition as undergraduate, UPR
_________________________________________
-
Publications
(from a total of 45):
Period 1997-2001
Weisman, G.A., Griffin,
K., Santiago-Pérez, L.I., Liu, J., Krugh, B., Flores, R.V., Chorna,
N., Santos-Berríos, C., Vivas-Mejía, P.E., Garrad, R.C.,
González, F.A., and Erb, L. (2001) "P2Y2 receptors regulate
multiple signal transduction pathways in monocytic cells." Drug Dev.
Res. 53, 186-192.
Erb, L., Liu, J.,
Ockerhausen, J., Kong, Q., Garrad, R.C., Griffin, K., Neal, C., Krugh,
B., Santiago-Perez, L.I., González F.A., Gresham, H.D., Turner,
J.T., and Weisman, G.A. (2001) "An RGD sequence in the P2Y2 receptor
interacts with aVb3 integrins and is required for Go-mediated signal transduction."
J. Cell. Biol. 153, 491-502.
Santiago-Pérez,
L.I., Flores, R.V., Santos-Berríos, C., Otero, M.A., Garrad, R.C.,
Erb, L., Weisman, G.A., and González, F.A. (2001) "P2Y2 nucleotide
receptor signaling in human monocytic cells: Activation, desensitization
and coupling to mitogen-activated protein kinases." J. Cell. Physiol.
187, 196-208.
Velázquez,
B., Garrad, R.C., Weisman, G.A., and Gonzalez, F.A. (2000) "Differential
agonist-induced desensitization of P2Y2 nucleotide receptors by ATP and
UTP." Mol. Cell. Biochem. 206, 75-89.
Otero, M., Garrad,
R.C., Velázquez, B., Hernández-Pérez, M.G., Camdem,
J.M., Erb, L., Clarke, L.L., Turner, J.T., Weisman, G.A., and González,
F.A., (2000) "Mechanisms of agonist-dependent and -independent desensitization
of a recombinant P2Y2 nucleotide receptor." Mol. Cell. Biochem. 205,115-123.
Clarke, L.L., Harline,
M.C., Otero, M.A., Glover, G.G., Garrad, R., Krugh, B., Walker, N.M.,
Gonzalez, F.A., Turner, J.T., and Weisman, G.A. (1999) "Desensitization
of P2Y2 receptor-activated transepithelial anion secretion." Am.
J. Physiol.(Cell Physiol.) 276, C777-C787.
Weisman, G.A., Garrad,
R.C., Erb, L.J., Santos-Berrios, C., and Gonzalez, F.A. (1999) P2Y receptors
in the nervous system: Molecular studies of a P2Y2 receptor subtype from
NG108-15 neuroblatoma X glioma hybrid cells. Prog. Brain Res. 120, 33-43.
Weisman, G.A., Erb,
L., Garrad, R.C., Theiss, P.M., Turner, J.T., Santiago-Perez, L.I., Flores,
R.V., Santos-Berrios, C., Mendez, Y., and Gonzalez, F.A. (1998) P2Y nucleotide
receptors in the immune system: Studies of a P2Y2 receptor in U937 cells.
Drug Dev. Res. 45, 222-228.
Carballeira, N.M.,
Emiliano, A., Hernández-Alonso, N., and Gonzalez, F.A. (1998) Facile
synthesis and antimicrobial activity of the marine fatty acids (Z)-2-methoxy-5-hexadecenoic
acid and (Z)-2-methoxy-6-hexadecenoic acid. J Nat. Prod. 61, 1543-1546.
Garrad, R.C., Otero,
M., Erb, L., Theiss, P.M., Clarke, L.L., Gonzalez, F.A., Turner, J.T.,
and Weisman, G.A. (1998) "Structural basis of agonist-induced desensitization
and sequestration of the P2Y2 nucleotide receptor: Consequences of truncation
of the C-terminus." J. Biol. Chem. 273, 29437-29444.
Weisman, G.A., Garrad,
R.C., Erb, L.J., Otero, M., Gonzalez, F.A., and Clarke, L.L. (1998) "Structure
and function of P2Y2 nucleotide receptors in cystic fibrosis (CF) epithelium."
Adv. Exp. Med. Biol. 431, 417-424.
Lozano, C.M., Cox,
O., Muir, M.M., Morales, J.D., Rodríguez-Cabán, J.L., Vivas-Mejía,
P.E., and Gonzalez, F.A. (1998) "Novel cytotoxic anionic tribromo
platinum (II) complexes containing benzothiazole and benzoxazole donors.
Synthesis, characterization and structure-activity correlation."
Inorg. Chim Acta. 271, 137-144.
Weisman, G.A., Gonzalez,
F.A., Erb, L., Garrad, R.C., and Turner, J.T. (1998) "Chapter 3:
The cloning and expression of G protein-coupled P2Y nucleotide receptors."
In: The P2 Nucleotide Receptors, Eds. J.T. Turner, G.A Weisman and J.S.
Fedan, Humana Press, 1998, pp. 63-79.
Vivas-Mejía,
P.E., Cox, O., and Gonzalez, F.A. (1998) "Inhibition of human topoisomerase
II by anti-neoplastic benzazolo[3,2-a]quinolinium chlorides." Mol.
Cell. Biochem. 178, 203-212.
Vivas-Mejía,
P.E., Rodríguez-Cabán, J.L., Díaz-Velázquez,
M., Hernández-Pérez, M.G., Cox, O., and González,
F.A. (1997) "DNA binding-independent anti-proliferative action of
benzazolo[3,2-a]quinolinium DNA intercalators." Mol. Cell. Biochem.
177, 69-77.
Carballeira, N.M.,
Reyes, E.D., Sostre, A., Rodriguez, A.D., Rodriguez, J.L., and Gonzalez,
F.A. (1997) "Identification of the novel antimicrobial fatty acid
(5Z,9Z)-14-methyl-5,9-pentadecadienoic in Eunicea succinea." J. Nat.
Prod. 60, 502-504.
Chavez, P.I., Sánchez,
L.A., González, F.A., Rodríguez, J.L., and Axelrod, F. (1997)
"Cytotoxicity correlations of Puerto Rican plants using a simplified
brine shrimp lethality screening procedure." Int. J. Pharmacog. 35,
222-226.
Weisman, G.A., Turner,
J.T., Clarke, L.L., Gonzalez, F.A., Otero, M.A., Garrad, R.C., and Erb,
L. (1997) "P2 Nucleotide Receptor Structure and Function." In:
Ecto-ATPases: Recent Progresson Structure and Function, Eds. L. Plesner,
T.L. Kirley, and A.F. Knowles. Plenum Press, 1997 pp. 231-237.
|
